Fruits and barks extracts of Zanthozyllum heitzii a spice from Cameroon induce mitochondrial dependent apoptosis and Go/G1 phase arrest in human leukemia HL-60 cells
Identifieur interne : 000A78 ( Main/Exploration ); précédent : 000A77; suivant : 000A79Fruits and barks extracts of Zanthozyllum heitzii a spice from Cameroon induce mitochondrial dependent apoptosis and Go/G1 phase arrest in human leukemia HL-60 cells
Auteurs : Constant Anatole Pieme [Cameroun, Inde] ; Guru Kumar Santosh [Inde] ; Emmanuel Mouafo Tekwu [Cameroun, Turquie] ; Tülin Askun [Turquie] ; Hatice Aydeniz [Turquie] ; Jeanne Yonkeu Ngogang [Cameroun] ; Shashi Bhushan [Inde] ; Ajit Kumar Saxena [Inde]Source :
- Biological Research [ 0716-9760 ] ; 2014.
Abstract
This study was aimed to determine the antiproliferative effects of four extracts from the fruits and barks of
The phytochemical analysis of the extracts indicated the presence of four known polyphenols (Syringic acid, Juglon, Luteolin and Myricetin) in both fruits and barks of
Polyphenols from
Url:
DOI: 10.1186/0717-6287-47-54
PubMed: 25723957
PubMed Central: 4335363
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000653
- to stream Pmc, to step Curation: 000652
- to stream Pmc, to step Checkpoint: 000820
- to stream Ncbi, to step Merge: 001A17
- to stream Ncbi, to step Curation: 001A17
- to stream Ncbi, to step Checkpoint: 001A17
- to stream Main, to step Merge: 000A79
- to stream Main, to step Curation: 000A78
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Fruits and barks extracts of <italic>Zanthozyllum heitzii</italic> a spice from Cameroon induce mitochondrial dependent apoptosis and Go/G1 phase arrest in human leukemia HL-60 cells</title><author><name sortKey="Pieme, Constant Anatole" sort="Pieme, Constant Anatole" uniqKey="Pieme C" first="Constant Anatole" last="Pieme">Constant Anatole Pieme</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, PO BOX 1364, Yaoundé, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, PO BOX 1364, Yaoundé</wicri:regionArea><wicri:noRegion>Yaoundé</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, 18001 Jammu, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, 18001 Jammu</wicri:regionArea><wicri:noRegion>18001 Jammu</wicri:noRegion></affiliation></author><author><name sortKey="Santosh, Guru Kumar" sort="Santosh, Guru Kumar" uniqKey="Santosh G" first="Guru Kumar" last="Santosh">Guru Kumar Santosh</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, 18001 Jammu, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, 18001 Jammu</wicri:regionArea><wicri:noRegion>18001 Jammu</wicri:noRegion></affiliation></author><author><name sortKey="Tekwu, Emmanuel Mouafo" sort="Tekwu, Emmanuel Mouafo" uniqKey="Tekwu E" first="Emmanuel Mouafo" last="Tekwu">Emmanuel Mouafo Tekwu</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Laboratory for TB research, Biotechnology Centre, Faculty of Science, University of Yaoundé 1, PO BOX 812, Yaoundé, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Laboratory for TB research, Biotechnology Centre, Faculty of Science, University of Yaoundé 1, PO BOX 812, Yaoundé</wicri:regionArea><wicri:noRegion>Yaoundé</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff4">Department of Biology, Faculty of Sciences and Arts, University of Balikesir, Cagis Campus, 10145 Balikesir, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Biology, Faculty of Sciences and Arts, University of Balikesir, Cagis Campus, 10145 Balikesir</wicri:regionArea><wicri:noRegion>10145 Balikesir</wicri:noRegion></affiliation></author><author><name sortKey="Askun, Tulin" sort="Askun, Tulin" uniqKey="Askun T" first="Tülin" last="Askun">Tülin Askun</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Department of Biology, Faculty of Sciences and Arts, University of Balikesir, Cagis Campus, 10145 Balikesir, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Biology, Faculty of Sciences and Arts, University of Balikesir, Cagis Campus, 10145 Balikesir</wicri:regionArea><wicri:noRegion>10145 Balikesir</wicri:noRegion></affiliation></author><author><name sortKey="Aydeniz, Hatice" sort="Aydeniz, Hatice" uniqKey="Aydeniz H" first="Hatice" last="Aydeniz">Hatice Aydeniz</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Department of Biology, Faculty of Sciences and Arts, University of Balikesir, Cagis Campus, 10145 Balikesir, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Biology, Faculty of Sciences and Arts, University of Balikesir, Cagis Campus, 10145 Balikesir</wicri:regionArea><wicri:noRegion>10145 Balikesir</wicri:noRegion></affiliation></author><author><name sortKey="Ngogang, Jeanne Yonkeu" sort="Ngogang, Jeanne Yonkeu" uniqKey="Ngogang J" first="Jeanne Yonkeu" last="Ngogang">Jeanne Yonkeu Ngogang</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, PO BOX 1364, Yaoundé, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, PO BOX 1364, Yaoundé</wicri:regionArea><wicri:noRegion>Yaoundé</wicri:noRegion></affiliation></author><author><name sortKey="Bhushan, Shashi" sort="Bhushan, Shashi" uniqKey="Bhushan S" first="Shashi" last="Bhushan">Shashi Bhushan</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, 18001 Jammu, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, 18001 Jammu</wicri:regionArea><wicri:noRegion>18001 Jammu</wicri:noRegion></affiliation></author><author><name sortKey="Saxena, Ajit Kumar" sort="Saxena, Ajit Kumar" uniqKey="Saxena A" first="Ajit Kumar" last="Saxena">Ajit Kumar Saxena</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, 18001 Jammu, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, 18001 Jammu</wicri:regionArea><wicri:noRegion>18001 Jammu</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25723957</idno><idno type="pmc">4335363</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335363</idno><idno type="RBID">PMC:4335363</idno><idno type="doi">10.1186/0717-6287-47-54</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000653</idno><idno type="wicri:Area/Pmc/Curation">000652</idno><idno type="wicri:Area/Pmc/Checkpoint">000820</idno><idno type="wicri:Area/Ncbi/Merge">001A17</idno><idno type="wicri:Area/Ncbi/Curation">001A17</idno><idno type="wicri:Area/Ncbi/Checkpoint">001A17</idno><idno type="wicri:doubleKey">0716-9760:2014:Pieme C:fruits:and:barks</idno><idno type="wicri:Area/Main/Merge">000A79</idno><idno type="wicri:Area/Main/Curation">000A78</idno><idno type="wicri:Area/Main/Exploration">000A78</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Fruits and barks extracts of <italic>Zanthozyllum heitzii</italic> a spice from Cameroon induce mitochondrial dependent apoptosis and Go/G1 phase arrest in human leukemia HL-60 cells</title><author><name sortKey="Pieme, Constant Anatole" sort="Pieme, Constant Anatole" uniqKey="Pieme C" first="Constant Anatole" last="Pieme">Constant Anatole Pieme</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, PO BOX 1364, Yaoundé, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, PO BOX 1364, Yaoundé</wicri:regionArea><wicri:noRegion>Yaoundé</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, 18001 Jammu, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, 18001 Jammu</wicri:regionArea><wicri:noRegion>18001 Jammu</wicri:noRegion></affiliation></author><author><name sortKey="Santosh, Guru Kumar" sort="Santosh, Guru Kumar" uniqKey="Santosh G" first="Guru Kumar" last="Santosh">Guru Kumar Santosh</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, 18001 Jammu, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, 18001 Jammu</wicri:regionArea><wicri:noRegion>18001 Jammu</wicri:noRegion></affiliation></author><author><name sortKey="Tekwu, Emmanuel Mouafo" sort="Tekwu, Emmanuel Mouafo" uniqKey="Tekwu E" first="Emmanuel Mouafo" last="Tekwu">Emmanuel Mouafo Tekwu</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Laboratory for TB research, Biotechnology Centre, Faculty of Science, University of Yaoundé 1, PO BOX 812, Yaoundé, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Laboratory for TB research, Biotechnology Centre, Faculty of Science, University of Yaoundé 1, PO BOX 812, Yaoundé</wicri:regionArea><wicri:noRegion>Yaoundé</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff4">Department of Biology, Faculty of Sciences and Arts, University of Balikesir, Cagis Campus, 10145 Balikesir, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Biology, Faculty of Sciences and Arts, University of Balikesir, Cagis Campus, 10145 Balikesir</wicri:regionArea><wicri:noRegion>10145 Balikesir</wicri:noRegion></affiliation></author><author><name sortKey="Askun, Tulin" sort="Askun, Tulin" uniqKey="Askun T" first="Tülin" last="Askun">Tülin Askun</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Department of Biology, Faculty of Sciences and Arts, University of Balikesir, Cagis Campus, 10145 Balikesir, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Biology, Faculty of Sciences and Arts, University of Balikesir, Cagis Campus, 10145 Balikesir</wicri:regionArea><wicri:noRegion>10145 Balikesir</wicri:noRegion></affiliation></author><author><name sortKey="Aydeniz, Hatice" sort="Aydeniz, Hatice" uniqKey="Aydeniz H" first="Hatice" last="Aydeniz">Hatice Aydeniz</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Department of Biology, Faculty of Sciences and Arts, University of Balikesir, Cagis Campus, 10145 Balikesir, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Biology, Faculty of Sciences and Arts, University of Balikesir, Cagis Campus, 10145 Balikesir</wicri:regionArea><wicri:noRegion>10145 Balikesir</wicri:noRegion></affiliation></author><author><name sortKey="Ngogang, Jeanne Yonkeu" sort="Ngogang, Jeanne Yonkeu" uniqKey="Ngogang J" first="Jeanne Yonkeu" last="Ngogang">Jeanne Yonkeu Ngogang</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, PO BOX 1364, Yaoundé, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, PO BOX 1364, Yaoundé</wicri:regionArea><wicri:noRegion>Yaoundé</wicri:noRegion></affiliation></author><author><name sortKey="Bhushan, Shashi" sort="Bhushan, Shashi" uniqKey="Bhushan S" first="Shashi" last="Bhushan">Shashi Bhushan</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, 18001 Jammu, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, 18001 Jammu</wicri:regionArea><wicri:noRegion>18001 Jammu</wicri:noRegion></affiliation></author><author><name sortKey="Saxena, Ajit Kumar" sort="Saxena, Ajit Kumar" uniqKey="Saxena A" first="Ajit Kumar" last="Saxena">Ajit Kumar Saxena</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, 18001 Jammu, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, 18001 Jammu</wicri:regionArea><wicri:noRegion>18001 Jammu</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biological Research</title><idno type="ISSN">0716-9760</idno><idno type="eISSN">0717-6287</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p><italic>Zanthoxylum heitzii</italic> is a spice used to prepare several dishes and to treat tumors, syphilis, malaria, cardiac palpitations, urogenital infections in the west region of Cameroon, but the antitumor mechanisms and chemical composition are not yet investigated.</p><p>This study was aimed to determine the antiproliferative effects of four extracts from the fruits and barks of <italic>Zanthoxyllum heitzii</italic> (Rutaceae) on apoptosis in human promyelocytic cells, their mechanisms and the chemical composition. The 3-(4, 5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to determine the fifty percent inhibition (IC<sub>50</sub>) concentration of the cell lines after treatment. The effect on morphology was observed using a light or fluorescence microscopy. The rate of apoptosis and the cell cycle were measured using flow cytometry (FCM). The phytochemical analysis of the extract was carried with HPLC/MS methods.</p></sec><sec><title>Results</title><p>The phytochemical analysis of the extracts indicated the presence of four known polyphenols (Syringic acid, Juglon, Luteolin and Myricetin) in both fruits and barks of <italic>Z. heitzii</italic> but in different quantities. Syringic acid and Myricetin concentrations were between 17-21 fold higher in the fruits than the stem bark. Rhamnetin (393.35 μg/mL) and Oleuropein (63.10 μg/mL) were identified only in the stem barks of <italic>Z. heitzii</italic>. Among the four extracts tested for cytotoxicity properties, only the methanol extract of fruits and barks significantly inhibited cell proliferation of HL-60 cells with IC<sub>50</sub> value of 20 μg/mL and 12 μg/mL respectively. HL-60 cells treated with <italic>Z. heitzii</italic> extracts significantly produced reactive oxygen species (ROS) with concurrent loss of mitochondrial membrane potential (MMP). Modifications in the DNA distribution and enhanced of G1/G0 phase cell cycle arrest were observed in a concentration dependent manner.</p></sec><sec><title>Conclusions</title><p>Polyphenols from <italic>Z. heitzii</italic> plant exert inhibitory effect on HL-60 cells through the reactive oxygen species (ROS) generation, loss of mitochondrial membrane potential and cell cycle destabilization.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Scalbert, A" uniqKey="Scalbert A">A Scalbert</name></author><author><name sortKey="Manach, C" uniqKey="Manach C">C Manach</name></author><author><name sortKey="Morand, C" uniqKey="Morand C">C Morand</name></author><author><name sortKey="Remesy, C" uniqKey="Remesy C">C Remesy</name></author><author><name sortKey="Jimenez, L" uniqKey="Jimenez L">L Jimenez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belkaid, A" uniqKey="Belkaid A">A Belkaid</name></author><author><name sortKey="Currie, Jc" uniqKey="Currie J">JC Currie</name></author><author><name sortKey="Desgagnes, J" uniqKey="Desgagnes J">J Desgagnes</name></author><author><name sortKey="Annabi, B" uniqKey="Annabi B">B Annabi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, X" uniqKey="Zhu X">X Zhu</name></author><author><name sortKey="Chen, B" uniqKey="Chen B">B Chen</name></author><author><name sortKey="Ma, M" uniqKey="Ma M">M Ma</name></author><author><name sortKey="Luo, X" uniqKey="Luo X">X Luo</name></author><author><name sortKey="Zhang, F" uniqKey="Zhang F">F Zhang</name></author><author><name sortKey="Yao, S" uniqKey="Yao S">S Yao</name></author><author><name sortKey="Wan, Z" uniqKey="Wan Z">Z Wan</name></author><author><name sortKey="Yang, D" uniqKey="Yang D">D Yang</name></author><author><name sortKey="Hang, H" uniqKey="Hang H">H Hang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cronquist, A" uniqKey="Cronquist A">A Cronquist</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heywood, V" uniqKey="Heywood V">V Heywood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mbaze, Lm" uniqKey="Mbaze L">LM Mbaze</name></author><author><name sortKey="Lado, Ja" uniqKey="Lado J">JA Lado</name></author><author><name sortKey="Wansi, Jd" uniqKey="Wansi J">JD Wansi</name></author><author><name sortKey="Shiao, Tc" uniqKey="Shiao T">TC Shiao</name></author><author><name sortKey="Chiozem, Dd" uniqKey="Chiozem D">DD Chiozem</name></author><author><name sortKey="Mesaik, Ma" uniqKey="Mesaik M">MA Mesaik</name></author><author><name sortKey="Choudhary, Mi" uniqKey="Choudhary M">MI Choudhary</name></author><author><name sortKey="Lacaille Dubois, Ma" uniqKey="Lacaille Dubois M">MA Lacaille-Dubois</name></author><author><name sortKey="Wandji, J" uniqKey="Wandji J">J Wandji</name></author><author><name sortKey="Roy, R" uniqKey="Roy R">R Roy</name></author><author><name sortKey="Sewald, N" uniqKey="Sewald N">N Sewald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ngouela, S" uniqKey="Ngouela S">S Ngouela</name></author><author><name sortKey="Tsamo, E" uniqKey="Tsamo E">E Tsamo</name></author><author><name sortKey="Connolly, Jd" uniqKey="Connolly J">JD Connolly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bongui, Jb" uniqKey="Bongui J">JB Bongui</name></author><author><name sortKey="Elomri, A" uniqKey="Elomri A">A Elomri</name></author><author><name sortKey="Cahard, D" uniqKey="Cahard D">D Cahard</name></author><author><name sortKey="Tillequin, F" uniqKey="Tillequin F">F Tillequin</name></author><author><name sortKey="Pfeiffer, B" uniqKey="Pfeiffer B">B Pfeiffer</name></author><author><name sortKey="Pierre, A" uniqKey="Pierre A">A Pierre</name></author><author><name sortKey="Seguin, E" uniqKey="Seguin E">E Seguin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zirihi, Gn" uniqKey="Zirihi G">GN Zirihi</name></author><author><name sortKey="Mambu, L" uniqKey="Mambu L">L Mambu</name></author><author><name sortKey="Guede Guina, F" uniqKey="Guede Guina F">F Guede-Guina</name></author><author><name sortKey="Bodo, B" uniqKey="Bodo B">B Bodo</name></author><author><name sortKey="Grellier, P" uniqKey="Grellier P">P Grellier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tchiegang, C" uniqKey="Tchiegang C">C Tchiégang</name></author><author><name sortKey="Mbougueng, P" uniqKey="Mbougueng P">P Mbougueng</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Nanfack, P" uniqKey="Nanfack P">P Nanfack</name></author><author><name sortKey="Biapa Nya, Pc" uniqKey="Biapa Nya P">PC Biapa Nya</name></author><author><name sortKey="Pieme, Ca" uniqKey="Pieme C">CA Pieme</name></author><author><name sortKey="Ama Moor, Vj" uniqKey="Ama Moor V">VJ Ama Moor</name></author><author><name sortKey="Mokette Moukette, B" uniqKey="Mokette Moukette B">B Mokette Moukette</name></author><author><name sortKey="Ngogang, Yj" uniqKey="Ngogang Y">YJ Ngogang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lembe, D" uniqKey="Lembe D">D Lembè</name></author><author><name sortKey="Domkam, J" uniqKey="Domkam J">J Domkam</name></author><author><name sortKey="Oundoum Oundoum, P" uniqKey="Oundoum Oundoum P">P Oundoum Oundoum</name></author><author><name sortKey="Ngaha Njila, M" uniqKey="Ngaha Njila M">M Ngaha Njila</name></author><author><name sortKey="Bend, F" uniqKey="Bend F">F Bend</name></author><author><name sortKey="Dongho Dogmo, F" uniqKey="Dongho Dogmo F">F Dongho Dogmo</name></author><author><name sortKey="Dimo, T" uniqKey="Dimo T">T Dimo</name></author><author><name sortKey="Gonzales, G" uniqKey="Gonzales G">G Gonzales</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mokondjimobe, E" uniqKey="Mokondjimobe E">E Mokondjimobe</name></author><author><name sortKey="Basilua Joe, M" uniqKey="Basilua Joe M">M Basilua Joe</name></author><author><name sortKey="Barkha, S" uniqKey="Barkha S">S Barkha</name></author><author><name sortKey="Dzeufiet, Pd" uniqKey="Dzeufiet P">PD Dzeufiet</name></author><author><name sortKey="Chenal, H" uniqKey="Chenal H">H Chenal</name></author><author><name sortKey="Otsudi Ndjeka, J B" uniqKey="Otsudi Ndjeka J">J-B Otsudi’andjeka</name></author><author><name sortKey="Bipolo, S" uniqKey="Bipolo S">S Bipolo</name></author><author><name sortKey="Besse, M" uniqKey="Besse M">M Besse</name></author><author><name sortKey="Mamadou, G" uniqKey="Mamadou G">G Mamadou</name></author><author><name sortKey="Nzouzi, Nl" uniqKey="Nzouzi N">NL Nzouzi</name></author><author><name sortKey="Kamtchouing, P" uniqKey="Kamtchouing P">P Kamtchouing</name></author><author><name sortKey="Meddah, B" uniqKey="Meddah B">B Meddah</name></author><author><name sortKey="Okpwae Okpwae, J" uniqKey="Okpwae Okpwae J">J Okpwae Okpwae</name></author><author><name sortKey="Schobiltgen, F" uniqKey="Schobiltgen F">F Schobiltgen</name></author><author><name sortKey="Eto, B" uniqKey="Eto B">B Eto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Hl" uniqKey="Yang H">HL Yang</name></author><author><name sortKey="Chang, Wh" uniqKey="Chang W">WH Chang</name></author><author><name sortKey="Chia, Yc" uniqKey="Chia Y">YC Chia</name></author><author><name sortKey="Huang, Cj" uniqKey="Huang C">CJ Huang</name></author><author><name sortKey="Lu, Fj" uniqKey="Lu F">FJ Lu</name></author><author><name sortKey="Hsu, Hk" uniqKey="Hsu H">HK Hsu</name></author><author><name sortKey="Hseu, Yc" uniqKey="Hseu Y">YC Hseu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pieme, Ca" uniqKey="Pieme C">CA Pieme</name></author><author><name sortKey="Ngogang, J" uniqKey="Ngogang J">J Ngogang</name></author><author><name sortKey="Costache, M" uniqKey="Costache M">M Costache</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, K" uniqKey="Kang K">K Kang</name></author><author><name sortKey="Lee, Hj" uniqKey="Lee H">HJ Lee</name></author><author><name sortKey="Kim, Cy" uniqKey="Kim C">CY Kim</name></author><author><name sortKey="Lee, Sb" uniqKey="Lee S">SB Lee</name></author><author><name sortKey="Tunsag, J" uniqKey="Tunsag J">J Tunsag</name></author><author><name sortKey="Batsuren, D" uniqKey="Batsuren D">D Batsuren</name></author><author><name sortKey="Nho, Cw" uniqKey="Nho C">CW Nho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Kc" uniqKey="Kim K">KC Kim</name></author><author><name sortKey="Kim, Js" uniqKey="Kim J">JS Kim</name></author><author><name sortKey="Son, Jk" uniqKey="Son J">JK Son</name></author><author><name sortKey="Kim, Ig" uniqKey="Kim I">IG Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rogalska, A" uniqKey="Rogalska A">A Rogalska</name></author><author><name sortKey="Koceva Chyla, A" uniqKey="Koceva Chyla A">A Koceva-Chyla</name></author><author><name sortKey="Jozwiak, Z" uniqKey="Jozwiak Z">Z Jozwiak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Y T" uniqKey="Huang Y">Y-T Huang</name></author><author><name sortKey="Huang, Y H" uniqKey="Huang Y">Y-H Huang</name></author><author><name sortKey="Hour, T C" uniqKey="Hour T">T-C Hour</name></author><author><name sortKey="Pan, Bs" uniqKey="Pan B">BS Pan</name></author><author><name sortKey="Liu, Y C" uniqKey="Liu Y">Y-C Liu</name></author><author><name sortKey="Pan, M H" uniqKey="Pan M">M-H Pan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shen, Hm" uniqKey="Shen H">HM Shen</name></author><author><name sortKey="Liu, Zg" uniqKey="Liu Z">ZG Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Malik, F" uniqKey="Malik F">F Malik</name></author><author><name sortKey="Kumar, A" uniqKey="Kumar A">A Kumar</name></author><author><name sortKey="Bhushan, S" uniqKey="Bhushan S">S Bhushan</name></author><author><name sortKey="Khan, S" uniqKey="Khan S">S Khan</name></author><author><name sortKey="Bhatia, A" uniqKey="Bhatia A">A Bhatia</name></author><author><name sortKey="Suri, K" uniqKey="Suri K">K Suri</name></author><author><name sortKey="Qazi, G" uniqKey="Qazi G">G Qazi</name></author><author><name sortKey="Singh, J" uniqKey="Singh J">J Singh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Juan, Me" uniqKey="Juan M">ME Juan</name></author><author><name sortKey="Wenzel, U" uniqKey="Wenzel U">U Wenzel</name></author><author><name sortKey="Daniel, H" uniqKey="Daniel H">H Daniel</name></author><author><name sortKey="Planas, Jm" uniqKey="Planas J">JM Planas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia, A" uniqKey="Garcia A">A Garcia</name></author><author><name sortKey="Morales, P" uniqKey="Morales P">P Morales</name></author><author><name sortKey="Arranz, N" uniqKey="Arranz N">N Arranz</name></author><author><name sortKey="Delgado, Me" uniqKey="Delgado M">ME Delgado</name></author><author><name sortKey="Rafter, J" uniqKey="Rafter J">J Rafter</name></author><author><name sortKey="Haza, Ai" uniqKey="Haza A">AI Haza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="D Utreaux, B" uniqKey="D Utreaux B">B D’Autreaux</name></author><author><name sortKey="Toledano, Mb" uniqKey="Toledano M">MB Toledano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peng, Cy" uniqKey="Peng C">CY Peng</name></author><author><name sortKey="Jiang, J" uniqKey="Jiang J">J Jiang</name></author><author><name sortKey="Zheng, Ht" uniqKey="Zheng H">HT Zheng</name></author><author><name sortKey="Liu, Xs" uniqKey="Liu X">XS Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dong, X" uniqKey="Dong X">X Dong</name></author><author><name sortKey="Bin, Q" uniqKey="Bin Q">Q Bin</name></author><author><name sortKey="Zhi Qiang, G" uniqKey="Zhi Qiang G">G Zhi-Qiang</name></author><author><name sortKey="Ying, J" uniqKey="Ying J">J Ying</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chowdhury, I" uniqKey="Chowdhury I">I Chowdhury</name></author><author><name sortKey="Tharakan, B" uniqKey="Tharakan B">B Tharakan</name></author><author><name sortKey="Bhat, Gk" uniqKey="Bhat G">GK Bhat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, S" uniqKey="Jin S">S Jin</name></author><author><name sortKey="Zhang, Qy" uniqKey="Zhang Q">QY Zhang</name></author><author><name sortKey="Kang, Xm" uniqKey="Kang X">XM Kang</name></author><author><name sortKey="Wang, Jx" uniqKey="Wang J">JX Wang</name></author><author><name sortKey="Zhao, Wh" uniqKey="Zhao W">WH Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abeysinghe, Dc" uniqKey="Abeysinghe D">DC Abeysinghe</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author><author><name sortKey="Sun, Cd" uniqKey="Sun C">CD Sun</name></author><author><name sortKey="Zhang, Ws" uniqKey="Zhang W">WS Zhang</name></author><author><name sortKey="Zhou, Ch" uniqKey="Zhou C">CH Zhou</name></author><author><name sortKey="Chen, Ks" uniqKey="Chen K">KS Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kelebek, H" uniqKey="Kelebek H">H Kelebek</name></author><author><name sortKey="Canbas, A" uniqKey="Canbas A">A Canbas</name></author><author><name sortKey="Selli, S" uniqKey="Selli S">S Selli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, G" uniqKey="Xu G">G Xu</name></author><author><name sortKey="Liu, D" uniqKey="Liu D">D Liu</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Ye, X" uniqKey="Ye X">X Ye</name></author><author><name sortKey="Ma, Y" uniqKey="Ma Y">Y Ma</name></author><author><name sortKey="Shi, J" uniqKey="Shi J">J Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohammed, F" uniqKey="Mohammed F">F Mohammed</name></author><author><name sortKey="Nagendra, P" uniqKey="Nagendra P">P Nagendra</name></author><author><name sortKey="Kong, K" uniqKey="Kong K">K Kong</name></author><author><name sortKey="Amin, I" uniqKey="Amin I">I Amin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kampa, M" uniqKey="Kampa M">M Kampa</name></author><author><name sortKey="Alexaki, Vi" uniqKey="Alexaki V">VI Alexaki</name></author><author><name sortKey="Notas, G" uniqKey="Notas G">G Notas</name></author><author><name sortKey="Nifli, Ap" uniqKey="Nifli A">AP Nifli</name></author><author><name sortKey="Nistikaki, A" uniqKey="Nistikaki A">A Nistikaki</name></author><author><name sortKey="Hatzoglou, A" uniqKey="Hatzoglou A">A Hatzoglou</name></author><author><name sortKey="Bakogeorgou, E" uniqKey="Bakogeorgou E">E Bakogeorgou</name></author><author><name sortKey="Kouimtzoglou, E" uniqKey="Kouimtzoglou E">E Kouimtzoglou</name></author><author><name sortKey="Blekas, G" uniqKey="Blekas G">G Blekas</name></author><author><name sortKey="Boskou, D" uniqKey="Boskou D">D Boskou</name></author><author><name sortKey="Gravanis, A" uniqKey="Gravanis A">A Gravanis</name></author><author><name sortKey="Castanas, E" uniqKey="Castanas E">E Castanas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zielinska Przyjemska, M" uniqKey="Zielinska Przyjemska M">M Zielinska-Przyjemska</name></author><author><name sortKey="Ignatowicz, E" uniqKey="Ignatowicz E">E Ignatowicz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="L Pez, L" uniqKey="L Pez L">L López</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vinayagam, R" uniqKey="Vinayagam R">R Vinayagam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ting Ting, W" uniqKey="Ting Ting W">W Ting-Ting</name></author><author><name sortKey="Shao Kang, W" uniqKey="Shao Kang W">W Shao-Kang</name></author><author><name sortKey="Gui Ling, H" uniqKey="Gui Ling H">H Gui-Ling</name></author><author><name sortKey="Gui Ju, S" uniqKey="Gui Ju S">S Gui-Ju</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yasmine, S" uniqKey="Yasmine S">S Yasmine</name></author><author><name sortKey="Fellous, A" uniqKey="Fellous A">A Fellous</name></author><author><name sortKey="Scherman, D" uniqKey="Scherman D">D Scherman</name></author><author><name sortKey="Chabot, G" uniqKey="Chabot G">G Chabot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vinson, Ja" uniqKey="Vinson J">JA Vinson</name></author><author><name sortKey="Liang, X" uniqKey="Liang X">X Liang</name></author><author><name sortKey="Proch, J" uniqKey="Proch J">J Proch</name></author><author><name sortKey="Hontz, Ba" uniqKey="Hontz B">BA Hontz</name></author><author><name sortKey="Dancel, J" uniqKey="Dancel J">J Dancel</name></author><author><name sortKey="Sandone, N" uniqKey="Sandone N">N Sandone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monika, M" uniqKey="Monika M">M Monika</name></author><author><name sortKey="Michal, S" uniqKey="Michal S">S Michał</name></author><author><name sortKey="Malgorzta, P" uniqKey="Malgorzta P">P Małgorzta</name></author><author><name sortKey="Hanna, C" uniqKey="Hanna C">C Hanna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nawal, H" uniqKey="Nawal H">H Nawal</name></author><author><name sortKey="Atta, E" uniqKey="Atta E">E Atta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bhushan, S" uniqKey="Bhushan S">S Bhushan</name></author><author><name sortKey="Kumar, A" uniqKey="Kumar A">A Kumar</name></author><author><name sortKey="Malik, F" uniqKey="Malik F">F Malik</name></author><author><name sortKey="Andotra, Ss" uniqKey="Andotra S">SS Andotra</name></author><author><name sortKey="Sethi, Vk" uniqKey="Sethi V">VK Sethi</name></author><author><name sortKey="Kaur, Ip" uniqKey="Kaur I">IP Kaur</name></author><author><name sortKey="Taneja, Sc" uniqKey="Taneja S">SC Taneja</name></author><author><name sortKey="Qazi, Gn" uniqKey="Qazi G">GN Qazi</name></author><author><name sortKey="Singh, J" uniqKey="Singh J">J Singh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bhushan, S" uniqKey="Bhushan S">S Bhushan</name></author><author><name sortKey="Kakkar, V" uniqKey="Kakkar V">V Kakkar</name></author><author><name sortKey="Pal, Hc" uniqKey="Pal H">HC Pal</name></author><author><name sortKey="Guru, Sk" uniqKey="Guru S">SK Guru</name></author><author><name sortKey="Kumar, A" uniqKey="Kumar A">A Kumar</name></author><author><name sortKey="Mondhe, Dm" uniqKey="Mondhe D">DM Mondhe</name></author><author><name sortKey="Sharma, Pr" uniqKey="Sharma P">PR Sharma</name></author><author><name sortKey="Taneja, Sc" uniqKey="Taneja S">SC Taneja</name></author><author><name sortKey="Kaur, Ip" uniqKey="Kaur I">IP Kaur</name></author><author><name sortKey="Singh, J" uniqKey="Singh J">J Singh</name></author><author><name sortKey="Saxena, Ak" uniqKey="Saxena A">AK Saxena</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caponio, F" uniqKey="Caponio F">F Caponio</name></author><author><name sortKey="Alloggio, V" uniqKey="Alloggio V">V Alloggio</name></author><author><name sortKey="Gomes, T" uniqKey="Gomes T">T Gomes</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Cameroun</li><li>Inde</li><li>Turquie</li></country></list><tree><country name="Cameroun"><noRegion><name sortKey="Pieme, Constant Anatole" sort="Pieme, Constant Anatole" uniqKey="Pieme C" first="Constant Anatole" last="Pieme">Constant Anatole Pieme</name></noRegion><name sortKey="Ngogang, Jeanne Yonkeu" sort="Ngogang, Jeanne Yonkeu" uniqKey="Ngogang J" first="Jeanne Yonkeu" last="Ngogang">Jeanne Yonkeu Ngogang</name><name sortKey="Tekwu, Emmanuel Mouafo" sort="Tekwu, Emmanuel Mouafo" uniqKey="Tekwu E" first="Emmanuel Mouafo" last="Tekwu">Emmanuel Mouafo Tekwu</name></country><country name="Inde"><noRegion><name sortKey="Pieme, Constant Anatole" sort="Pieme, Constant Anatole" uniqKey="Pieme C" first="Constant Anatole" last="Pieme">Constant Anatole Pieme</name></noRegion><name sortKey="Bhushan, Shashi" sort="Bhushan, Shashi" uniqKey="Bhushan S" first="Shashi" last="Bhushan">Shashi Bhushan</name><name sortKey="Santosh, Guru Kumar" sort="Santosh, Guru Kumar" uniqKey="Santosh G" first="Guru Kumar" last="Santosh">Guru Kumar Santosh</name><name sortKey="Saxena, Ajit Kumar" sort="Saxena, Ajit Kumar" uniqKey="Saxena A" first="Ajit Kumar" last="Saxena">Ajit Kumar Saxena</name></country><country name="Turquie"><noRegion><name sortKey="Tekwu, Emmanuel Mouafo" sort="Tekwu, Emmanuel Mouafo" uniqKey="Tekwu E" first="Emmanuel Mouafo" last="Tekwu">Emmanuel Mouafo Tekwu</name></noRegion><name sortKey="Askun, Tulin" sort="Askun, Tulin" uniqKey="Askun T" first="Tülin" last="Askun">Tülin Askun</name><name sortKey="Aydeniz, Hatice" sort="Aydeniz, Hatice" uniqKey="Aydeniz H" first="Hatice" last="Aydeniz">Hatice Aydeniz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/OrangerV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A78 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A78 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Bois
|area= OrangerV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4335363
|texte= Fruits and barks extracts of Zanthozyllum heitzii a spice from Cameroon induce mitochondrial dependent apoptosis and Go/G1 phase arrest in human leukemia HL-60 cells
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25723957" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a OrangerV1
| This area was generated with Dilib version V0.6.25. |  |